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Dr K K Aggarwal

Very low-calorie diet mimics benefits of bariatric surgery

By Dr K K Aggarwal
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Marked improvement in blood sugar control occurs in patients with type 2 diabetes mellitus soon after Roux–en–Y gastric bypass surgery (RYGB) and prior to major weight loss.

A study evaluated whether the magnitude of this change is mainly a result of caloric restriction or is unique to the surgical procedure. Eleven hospitalized subjects who underwent RYGB and 14 subjects mean-matched for BMI, HbA1c, and diabetes duration,received a very low-calorie diet of 500 kcal/day with a macronutrient content similar to that consumed by patients after RYGB.

Frequently sampled intravenous glucose tolerance tests were performed prior to and following the interventions.

Both groups lost an equivalent amount of weight over a mean period of 21 days. Insulin sensitivity, acute insulin secretion after intravenous glucose administration, and β-cell function, as determined by disposition index,were shown to improve to a similar extent in both the groups.

Changes in fasting glucose and fructosamine levels were also similar. The data therefore suggest that VLCD improves insulin sensitivity and β-cell function just as well as RYGB in the short-term.

Very low-calorie diet mimics benefits of bariatric surgery

By Dr K K Aggarwal
Filed Under Wellness | Tagged With: , , | | Comments Off on Very low-calorie diet mimics benefits of bariatric surgery

Marked improvement in blood sugar control occurs in patients with type 2 diabetes mellitus shortly after Roux-en-Y gastric bypass surgery (RYGB) and before there is major weight loss.

A study determined whether the magnitude of this change is primarily due to caloric restriction or is unique to the surgical procedure. Eleven hospitalized subjects who underwent RYGB and 14 subjects mean-matched for BMI, HbA1c, and diabetes duration were given a very low-calorie diet (VLCD) of 500 kcal/day with a macronutrient content similar to that consumed by patients after RYGB.

Frequently sampled intravenous glucose tolerance tests were performed before and after interventions.

Both groups lost an equivalent amount of weight over a mean study period of 21 days. Insulin sensitivity, acute insulin secretion after intravenous glucose administration, and β-cell function, as determined by disposition index, improved to a similar extent in both groups.

Likewise, changes in fasting glucose and fructosamine levels were similar. Based on these data, VLCD improves insulin sensitivity and β-cell function just as well as RYGB in the short-term.

Very low-calorie diet mimics benefits of bariatric surgery

By Dr K K Aggarwal
Filed Under Wellness | Tagged With: , | | Comments Off on Very low-calorie diet mimics benefits of bariatric surgery

Marked improvement in blood sugar control occurs in patients with type 2 diabetes mellitus shortly after Roux–en–Y gastric bypass surgery (RYGB) and before there is major weight loss.

A study determined whether the magnitude of this change is primarily due to caloric restriction or is unique to the surgical procedure. Eleven hospitalized subjects who underwent RYGB and 14 subjects mean-matched for BMI, HbA1c, and diabetes duration were given a very low-calorie diet of 500 kcal/day with a macronutrient content similar to that consumed by patients after RYGB.

Frequently sampled intravenous glucose tolerance tests were performed before and after interventions.

Both groups lost an equivalent amount of weight over a mean study period of 21 days. Insulin sensitivity, acute insulin secretion after intravenous glucose administration, and β-cell function as determined by disposition index improved to a similar extent in both groups.

Likewise, changes in fasting glucose and fructosamine levels were similar. Based on these data, VLCD improves insulin sensitivity and β-cell function just as well as RYGB in the short-term.

Very low–calorie diet mimics benefits of bariatric surgery

By Dr K K Aggarwal
Filed Under Wellness | Tagged With: , , | | Comments Off on Very low–calorie diet mimics benefits of bariatric surgery

Marked improvement in blood sugar control occurs in patients with type 2 diabetes mellitus shortly after Roux–en–Y gastric bypass surgery (RYGB) and before there is major weight loss.

A study determined whether the magnitude of this change is primarily due to caloric restriction or is unique to the surgical procedure. Eleven hospitalized subjects who underwent RYGB and 14 subjects mean–matched for BMI, HbA1c, and diabetes duration were given a very low–calorie diet of 500 kcal/day with a macronutrient content similar to that consumed by patients after RYGB.

Frequently sampled intravenous glucose tolerance tests were performed before and after interventions. Both groups lost an equivalent amount of weight over a mean study period of 21 days. Insulin sensitivity, acute insulin secretion after intravenous glucose administration, and β–cell function as determined by disposition index improved to a similar extent in both groups.

Likewise, changes in fasting glucose and fructosamine levels were similar. Based on these data, VLCD improves insulin sensitivity and β–cell function just as well as RYGB in the short term.

Treatment of Fatty Liver

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• 10 % weight loss can improve fatty liver and possibly inflammation.
• Metformin and ursodeoxycholic acid are not recommended.
• Statins are safe in patients with fatty liver but whether they can reduce fatty liver is not known.
• Omega-3 fatty acids have been tried
• Pioglitazone is useful in the treatment of biopsy-proven fatty liver with inflammation
• Vitamin E at a dose of 800 IU/day improves liver inflammation
• Use of bariatric surgery for treatment of fatty liver is premature and should be avoided in patients with cirrhosis.