Loss of a spouse to a heart attack is associated with a significant risk for depression and psychotropic medication use by the surviving partner as per a Danish study by Emil L. Fosbøl, MD, of Duke University published in European Heart Journal.

Compared with the year before the death of a spouse from an acute heart attack during the subsequent year the overall incidence rate ratio for use of an antidepressant was 3.30

In addition, during the month after the fatal heart attack there was a notably high rate of benzodiazepine use by surviving spouses.