The risk of cancer is increased in men taking amiodarone particularly in those with extensive exposure to the drug as per a retrospective study. Among men taking amiodarone, the risk for any cancer rose by almost 20% compared with the general population, according to Chia–Jen Liu, MD, of National Yang–Ming University Hospital in Yilan, Taiwan, and colleagues. And for men whose cumulative defined daily doses in a year exceeded 180, the risk was 46% higher the researchers reported online in Cancer.