Local bone denervation by MR–guided focused ultrasound has been demonstrated as a promising tool for pain palliation of bone metastases. A study in BMC Musculoskelet Disord 2013;14(267) has shown the safety and efficacy of MR–guided focused ultrasound treatment in osteoarthritis. Significant increase of pressure pain thresholds on treated area showed successful denervation effect on the nociceptive nerve terminals. MR–guided focused ultrasound is a promising and innovative procedure for noninvasive pain management of knee OA.