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Dr K K Aggarwal

Kidney patients more at risk for future heart attacks

By Dr K K Aggarwal
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Chronic kidney disease patients with kidney function less than 60% are included in the list of criteria for defining people at highest risk for future heart attacks.

In a large cohort Canadian study published in The Lancet led by Dr Marcello Tonelli at University of Alberta, patients with only chronic kidney disease had a significantly higher rate of heart attacks than those who only had diabetes. Those who had already had a heart attack had the highest overall rate of heart attacks.

Chronic kidney disease should be regarded as a coronary heart disease risk equivalent, similar to diabetes, as patients with the condition have high rates of cardiovascular events, particularly when they also have proteinuria. When chronic kidney disease was defined more stringently with kidney function less than 45% and increased proteinuria, the rate of first heart attack was higher in those with both chronic kidney disease and diabetes than in those with either disorder alone.

Diclofenac associated with increased risk of cardiovascular events

By Dr K K Aggarwal
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Diclofenac, used for the treatment of pain and inflammation caused by arthritis, is associated with a significantly increased risk of cardiovascular complications and should be removed from essential–medicines lists.

It is listed on the EML of 74 countries, increased the risk of cardiovascular events between 38% and 63% in different studies. The increased risk with diclofenac was similar to the COX-2 inhibitor rofecoxib, a drug withdrawn from worldwide markets because of cardiovascular toxicity.

Dr David Henry at Institute for Clinical Evaluative Sciences, Toronto who conducted the review along with Dr Patricia McGettigan at London School of Medicine and Dentistry said that its use is much more common in other non–Western countries.

Diclofenac associated with increased risk of cardiovascular events

By
Filed Under Wellness | Tagged With: , , | | Comments Off on Diclofenac associated with increased risk of cardiovascular events

Diclofenac, used for the treatment of pain and inflammation caused by arthritis, is associated with a significantly increased risk of cardiovascular complications and should be removed from essential-medicines lists.

It is listed on the EML of 74 countries, increased the risk of cardiovascular events between 38% and 63% in different studies. The increased risk with diclofenac was similar to the COX-2 inhibitor rofecoxib, a drug withdrawn from worldwide markets because of cardiovascular toxicity.

Dr David Henry at Institute for Clinical Evaluative Sciences,Toronto who conducted the review along with Dr Patricia McGettigan at London School of Medicine and Dentistry said that its use is much more common in other non-Western countries.