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Dr K K Aggarwal

Psoriasis, a complex immune�mediated disease

By Dr K K Aggarwal
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Psoriasis is a complex immune mediated disease and is a common disorder that affects men and women equally. The disease can manifest at any age however the peak times for disease onset are young adulthood ages 20 to 30 years and late middle age ages 50 to 69 years . There are several clinical subtypes of psoriasis. The most common presentation of psoriasis is plaque psoriasis which presents as sharply defined erythematous plaques with overlying silvery scales. The most commonly affected areas include scalp extensor surface of elbows knees and back. Psoriasis may also affect the joints. Psoriatic arthritis occurs in about 30 percent of patients with psoriasis and precedes the skin manifestations in about 15 percent of patients. In most patients a diagnosis of psoriasis can be made by history and physical examination. But sometimes a skin biopsy is needed to rule out other conditions. Numerous topical and systemic therapies are available for the treatment of psoriasis. The treatment approach for the individual patient depends on the severity of the disease relevant comorbidities patient preference including cost and convenience efficacy and evaluation of individual patient response.

Psoriasis Update

By Dr K K Aggarwal
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Psoriasis is a complex immune–mediated disease and is a common disorder that affects men and women equally. Although it can begin at any age, the peak times for disease onset are young adulthood (ages 20 to 30 years) and late middle age (ages 50 to 69 years). There are multiple clinical subtypes of psoriasis. Plaque psoriasis, the most common presentation of psoriasis, most commonly presents with sharply defined erythematous plaques with overlying silvery scales. The scalp, extensor elbows, knees, and back are common locations for plaque psoriasis lesions. Psoriatic arthritis occurs in about 30% of patients with psoriasis, and precedes the skin manifestations in approximately 15% of patients. A diagnosis of psoriasis can be made by history and physical examination in the vast majority of cases. Occasionally, a skin biopsy is needed to rule out other conditions. Numerous topical and systemic therapies are available for the treatment of psoriasis. Treatment modalities are chosen on the basis of disease severity, relevant comorbidities, patient preference (including cost and convenience), efficacy and evaluation of individual patient response.

Psoriasis Can Lead to Diabetes

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Psoriasis patients may be at an increased risk for type 2 diabetes, and the risk appears to be greatest among patients with severe psoriasis.

Compared with the general population, patients with mild psoriasis had a 49% increased risk of developing diabetes, and individuals with severe psoriasis had a 2.13-fold increased relative risk when compared with the general population, said Dr Ole Ahlehoff, post-doctoral fellow in cardiology at Copenhagen University Hospital Gentofte at the European Society of Cardiology meeting.